Release date: 2015-05-13 Recently, in a research paper published in the internationally renowned journal Nature Structural and Molecular Biology, scientists from the University of Illinois have identified a specific molecular structure that exists in the fine fibers of brain plaques. A hallmark of the onset of Alzheimer's disease, a molecule called beta amyloid-42, which is toxic to nerve cells and is thought to stimulate a cascade of diseases. Understanding the structure of the long-chain form of the amino acid amyloid-42 in the fiber is important to reveal how the amyloid beta is incorrectly folded and accumulates in the brain to form toxic plaques. Researcher Yoshitaka Ishii said that we found that amyloid-42 in amyloid fibrils can form three flat structures (called beta sheets) that can be flipped back and forth in the same layer in an S-type pattern. The final amino acid on the protein will form a "salt bridge" structure carrying an amino acid when the S-type is reversed for the first time to stabilize the entire protein structure; the salt bridge is a connection between a positively charged molecule and a negatively charged molecule or a part of a molecule. key. The structure of amyloid-42 and the amyloid-like-40 are very different. Beta amyloid-40 lacks a special terminal amino acid that can carry a very necessary negative for the formation of the "salt bridge" structure. Charge. Ishii said this may help explain why beta amyloid-42 does not interact with beta amyloid-40, or "recruit" it back into amyloid plaques. Revealing the structural properties and folding behavior of amyloid-42 may be a new perspective to understand the spread of amyloid in the brain of patients with neurodegenerative diseases such as Alzheimer's disease; and designed to resist amyloid- The 40 drug may not be resistant to the toxic effects of beta amyloid-42. The chemical nature of amyloid-42, especially its extremely "disgusting" water characteristics, may pose a major obstacle for scientists. Many laboratories are currently overcoming this obstacle, and researchers have also said that they are late This issue will also be addressed through more in-depth research, which will bring hope to the development of new targeted therapies for the treatment of Alzheimer's disease. Source: Bio Valley Ppe Nitrile Gloves,Aql4.0 Industrial Gloves,Ppe Non-Medical Equipment,Disposable Powder Free Nitrile Gloves Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshimedicals.com